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Additionally, AGEs reduce NO production and inhibit histamine-induced NO production in ECs [172]

This may make the kojic acid or glutathione feel too strong and may cause small cuts and irritation

Another limitation to the study is the use of subjective and informant-based instruments (SRS, ABC, SEC, CGI) due to the lack of reliable and readily available objective or performance-based instruments to measure the clinical severity of ASD and treatment outcomes