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the magnitude of the effect of cigarette smoking far outweighs all other factors. Moreover, the report emphasized that smoking is a health hazard of sufficient importance to warrant appropriate remedial action. Fifty years after the Surgeon Generals landmark report, the health and economic toll taken by smoking remains devastating

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Gan WQ, Cohen SB-Z, Paul Man SF, Sin DD: Sex-related differences in serum cotinine concentrations in daily cigarette smokers