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Methods We conducted experiments in which 3 groups of mice were pre-exposed to cigarette smoke for 8 weeks, followed by 8-week exposure to (1) HTPs ( tobacco product switching ), (2) air ( smoking cessation ), or (3) continued exposure to cigarette smoke

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In the presence of EZH2 overexpression, EZH2 inhibitor suppress the migration partly origin from inhibition of cell proliferation, induction of apoptosis or interruption of cell cycle promoting mechanism of cellular protection in the lung 44,45