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113, 114 The involvement of extracellular ATP and uric acid and the activation of the Nalp3inflammasome complex in the abrogation of inhalational tolerance and induction of aberrant Th2-driven inflammation by cigarette smoke represents an interesting working hypothesis for further investigation

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It is essential that this legislation is made a priority and introduced at the earliest opportunity to end tobacco marketing aimed at our children in Wales. Prof Drakeford also spoke about the potential of introducing a public health bill to tackle a wide range of public health issues

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