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It can also lead to cancer and heart disease in people who have never smoked

CS exposure increases the levels of miR-125a-5p in lung epithelial cells, which reduces levels of its target protein Sp1 and levels of SIRT1

Applauding the move, a campaigner Matthew Myers, said: "By increasing the tobacco age to 21, the nation's largest state provides incredible momentum to similar efforts nationwide." Tom Steyer, a leader of the Save Lives Campaign, has praised Brown's measures and said: "Despite threats from the big tobacco lobby, Governor Brown and the Legislature sent a clear message: We will do everything possible to save lives and protect our children from the deadly effects of tobacco," the New York Times has reported

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