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There have been clinical trials done on rats studying Adolescent Brain Cognitive Development (ABCD) which shows that THC affects the hippocampus (memory formation and information processing)

Smokers better off quitting, even with the risk of weight gain The nicotine in cigarettes can suppress appetite and boost metabolism

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While not all scientists agree, some studies indicate that vape contains only a fraction of the toxins of a traditional cigarette, plus its similarity to smoking makes it a smoother transition