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Various forms of tobacco products are used, including conventional cigarettes, waterpipe (shisha), smokeless tobacco, and electronic nicotine delivery systems (ENDS), such as electronic cigarettes (e-cigarettes) and vapes 7

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Most recently with the addition of immune checkpoint inhibitors such as nivolumab [70] or pembrolizumab [71] which prolongs disease-free survival after neoadjuvant chemoradiotherapy and surgery in patients with residual locally advanced esophageal squamous cell carcinoma, they are increasingly being incorporated into combined treatment strategies and are under investigation in both neoadjuvant and chemoradiation regimens