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Previous studies have found inconsistent results on whether smoking influences trait anxiety in humans (see for increased trait anxiety in smokers: 19

These characteristics, together with its well-established efficacy for the treatment of schizophrenia, the lower risk of extrapyramidal side effects compared to first-generation antipsychotics, and the lower risk of metabolic side effects compared to most second-generation antipsychotics [17], make aripiprazole an attractive alternative for the treatment of patients with schizophrenia with coexisting SUDs

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