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This reaction is strongly pH dependent and is expected to have a significant effect only at pH values of 6-7(3)

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On digital examination it feels hard and granular, and at proctoscopy, it appears as white plaques which may be diffuse, circumferential, or circumscribed

Funding This research was equally funded and supported by the Chinese National Science and Technology Major Project (2018ZX10305410), the Henan Province Medical Science and Technique Project grant (2018020001), the Henan Province Postdoctoral Research grant (001801005) and the Key Scientific Research Projects of Universities in Henan Province (21A320035)