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It may occur without cause, or it may be triggered by: Alcohol withdrawal Emotional stress Exposure to cold Medicines that cause narrowing of the blood vessels (vasoconstriction) Stimulant drugs, such as amphetamines and cocaine Cocaine use and cigarette smoking can cause severe spasms of the arteries

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Fetal/Neonatal adverse reactions Extrapyramidal and/or withdrawal symptoms, including agitation, hypertonia, hypotonia, tremor, somnolence, respiratory distress, and feeding disorder have been reported in neonates who have been exposed to antipsychotic drugs, including clozapine, during the third trimester of pregnancy