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doi:10.1016/j.mcna.2019.10.007 291

MOFs, with their customizable porosity and catalytic capabilities, have been utilized to deliver both ROS-generating and ROS-scavenging agents in a tumor-specific manner (He H

However, neurodegenerative disease mechanisms differ substantially between animal models and human diseases, and premature clinical use based solely on animal data could expose patients to unknown risks without established benefits

In some embodiments, the otic formulation or composition comprises between about 0.001% to about 40% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof