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Considering the rate of MVP observed in our cEDS cohort and the knowledge that the mitral valve depends upon collagen for its tensile strength and that myxomatous MVP is characterized by disruption of the collagen layer with expansion of glycosaminoglycans within the middle layer of the valve [123], it is reasonable to consider MVP as a potential clue for cEDS, although the true clinical significance is so far unknown

Counterfeits usually fail more than one

and second, from ambient air contained within the polyurethane foam below the fabric

Fibroblasts proliferate and deposit extracellular matrix, leading to scar formation and maintaining structural integrity