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Pharmacological inhibition of CETP (Cholesteryl Ester Transfer Protein) increases HDL (High-Density Lipoprotein) that contains ApoC3 and other HDL subspecies associated with higher risk of coronary heart disease

This is not surprising given that MRS has been historically used to study (a) high-concentration and easily detectable metabolites at lower field strengths, such as N-acetylaspartate, choline, creatine and myo-inositol (Cleeland et al., 2019, Huibregtse et al., 2021), and (b) low-concentration non-GSH metabolites such as gamma-aminobutyric acid and glutamate (Runia et al., 2022)

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