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The real challenge is to tweak the addictive effect of drugs like nicotine or other psychostimulants without totally crushing the persons desire to pursue healthy behavior. Future research will also focus on whether repeated exposure to nicotine, as would occur in a regular smoker, changes the drugs effects on synaptic plasticity in the VTA

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He told her to call him when she was ready to discuss what to do about the film

Its not just nicotine, though thats the major component