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For instance, compared to non-smokers, many smokers have a thin body frame, which is a risk factor for fragile bones, the National Institute of Arthritis and Musculoskeletal and Skin Diseases reports

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At a molecular level, smoking affects key signaling pathways such as nuclear factor-kappa B (NF-kB) and mitogen-activated protein kinases (MAPK) and induces epigenetic modifications like DNA methylation and histone modification [22]