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Through these reactions, vitamin B12 is associated with fat and carbohydrate metabolism and protein synthesis

In addition to these three dehydrogenases, TPP is a required co-factor for the transketolase catalyzed reactions of the pentose phosphate pathway and it is required for the catabolism of the methyl-substituted fatty acid (phytanic acid) at the 2-hydroxyphytanoyl-CoA lyase reaction

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Researchers attribute this rise in exposures to increases in prescriptions for these medications and an increase in therapeutic errors