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These findings tightly link ROS and Nrf2 to ER oxidative protein folding and calcium signaling, establishing a regulatory mechanism for protein oxidative folding-Nrf2-ER calcium axis (Figure 7)

"Once they're gone, you can't regenerate pigment any more - the damage is permanent." In another experiment, the researchers found they could block the changes by giving the mice an anti-hypertensive, which treats high blood pressure

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S-yX: Conceptualization, Funding acquisition, Writing original draft, Writing review & editing