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Scottish botanist David Douglas reported finding a tobacco garden near a village on the Multnomah River (the present-day Willamette River) in 1825: "An open place in the wood is chosen where there is dead wood, which they burn, and sow the seed in the ashes.I met the owner whotold me that wood ashes made it grow very large." Two decades earlier, Meriwether Lewis and William Clark had found that tobacco was being grown by groups they encountered during their trek to the Pacific

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Int J Oral Surg 1984