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And the appalling loss of his son

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Current evidence supports the dopaminergic hypothesis as one of the pathophysiological hypotheses for negative symptoms in SCZ, which proposes that positive symptoms are the result of overactive dopaminergic neurotransmission in the limbic pathway, whereas negative symptoms are thought to be caused by low dopaminergic function in the frontal lobes and other limbic structures of the midbrain 7,43

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