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and reduction of neurite adhesion to the substratum, which can impede neurite extension 58

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Effective treatments for neurological disorders are still lacking, primarily due to the presence of the blood-brain barrier (BBB), a unique and selective endothelial barrier that protects against neurotoxic substances, as well as prevents the movement of xenobiotics into the CNS, including pharmacological agents (Pardridge, 2005)

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