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Landmark 2017 Cell paper One of the foundational studies (by Baar et al.) was titled Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. This work demonstrated: In mice that were aged or given chemotherapy (accelerated ageing), treatment with FOXO4-DRI improved physical performance, fur quality, and renal function

Because the body's own GHK-Cu declines significantly with age, supplementing it is studied for restoring some of skin's youthful regenerative capacity which is why it appears in both medical and high-end skincare contexts

Ferroptosis affects the progression of nonalcoholic steatohepatitis via the modulation of lipid peroxidation-mediated cell death in mice