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4.2.2 Mechanism of action in dry eye disease LFs antioxidant properties on the ocular surface, where it chelates free iron and prevents the formation of harmful hydroxyl radicals, thus protecting CECs from oxidative stress (Pastori et al., 2015)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 33.El Skhawy N, Eissa MM

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There is a consensus that GPX and GCL are the two enzymes in the glutathione pathway that are upregulated by estradiol

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