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Retrieved 27 May 2017

People may be at higher risk for a B12 deficiency if they: Are age 50 and older: Several factors contribute to B12 deficiency in people over 50

They are potentially safer for long-term use because they work through natural biological mechanisms rather than forcing pathways shut

A good rule of thumb: wait until your rate of weight loss has slowed to less than 1 pound per week for at least three consecutive weeks despite consistent diet and exercise