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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations 8-OH-dg: 8-hydroxy-2-deoxyguanosine AM: airway macrophage BAL: bronchoalveolar lavage ELF: epithelial lining fluid GSH: glutathione (reduced form) GSSG: glutathione disulfide (oxidized form) HAT: histone acetyltransferase HDAC: histone deacetylase ICS: inhaled corticosteroid MDA: malondialdehyde PARP: poly (ADP-ribose) polymerase References Fitzpatrick AM, Gaston BM, Erzurum SC, Teague WG 2006 Features of severe asthma in school-age children: atopy and increased exhaled nitric oxide
369 The hyper-metabolism of cancer cells causes the excessive generation of ROS
For quality control, we excluded participants who (1) have excess relatedness (more than 10 putative third-degree relatives), (2) have inconsistent information about sex based on genotyping and self-report, (3) have sex-chromosomes not XX or XY, (4) have poor-quality genotyping based on heterozygosity and missing rates, or (5) have withdrawn from UK Biobank
Plasma HSP90AA1 predicts the risk of breast cancer onset and distant metastasis
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