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Global smoking prevalence

Tobacco smoking was associated with increased LV and RV end-systolic volume (4.98 2.08 mL, 5.19 2.62 mL, P = 0.018, 0.049 respectively), reduced LV and RV ejection fraction (: 2.21 0.82%, 2.06 0.87%, P = 0.007, 0.019 respectively), and reduced absolute measures of LV peak global longitudinal, radial, and circumferential strain (: 0.86 0.30%, 2.52 0.99%, 1.05 0.32%, P = 0.004, 0.011, 0.001 respectively)

Bailey by Magdalena Papaioannou

In vivo , blockade of IL-15 signaling with a neutralizing antibody significantly reduced liver injury in our murine AH model, suggesting that IL-15 signaling contributes to AH pathogenesis