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As far as game worlds go, Red Dead Redemption 2 is massive, and it has the characters and items needed to fill that world

Abbreviations 3-HC: 3-Hydroxycotinine AUDIT: Alcohol Use Disorders Identification Test CAMH: Centre for Addiction and Mental Health CPD: Cigarettes per day CO: Carbon monoxide CYP2A6: Cytochrome P450 2A6 DASS 21: Depression, Anxiety and Stress Scale DAST-10: Drug Abuse Screening Test FTND: Fagerstrm Test for Nicotine Dependence ITT: Intention-to-treat principle mCEQ: Modified Cigarette Evaluation Questionnaire MNWS: Minnesota Nicotine Withdrawal Scale NMR: Nicotine metabolite ratio (3-HC/cotinine) NRT: Nicotine replacement therapy UOHI: University of Ottawa Heart Institute PHQ-9: Patient Health Questionnaire PPA: Point prevalence abstinence QI: Qualified investigator QSU-brief: Questionnaire of Smoking Urges - Brief SF-36: 36-Item Short-Form Health Survey References Government of Canada

Between April-May 2020, the researchers conducted telephone interviews with adults across the United States who use cigarettes and/or electronic nicotine delivery systems (ENDS), such as e-cigarettes

Access information from the Centers for Disease Control and Prevention.