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The clearance of nicotine is more influenced by changes in hepatic blood flow than cotinine whose clearance is more dependent on enzymatic metabolism

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Supplementary appendix Overview and purpose of STARS A 2002 National Tobacco Monitoring, Research and Evaluation Workshop reviewed and identified improvements to the existing infrastructure for tobacco surveillance and evaluation.13 Focusing on tobacco brand pricing strategies, retail advertising and promotional allowances, the Vector Workgroup highlighted several problems with existing surveillance: laborious coding procedures, lack of standardised protocols and poor comparability between studies and across jurisdictions