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Over time, the brains cooling system wears down, leading to agitation, poor sleep, and cognitive fatigue

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It is normally synthesized in mature neurons in the granular cell layer of the dentate gyrus at much higher concentration than in other neurons of the brain and is localized in their axons (Scharfman, 2004)

In the context of LC pharmacological agents inhibiting harmful Ang II/AT 1 R axis by angiotensin receptor blockers (ARB), angiotensin-converting enzyme inhibitors (ACEI), and or pharmaceuticals which are activating protective ACE2/Ang 1-7/AT 2 R axis, for example Compound 21 (C21), can be used