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HPA hyperactivity during NPW We observed significant increases in plasma cortisol and in pituitary R1 (see the Methods section) that were consistent with HPA hyperactivity during NPW [78]

Caffeine: The Metabolic Pathways Involved in Biotransformation and Oxidative Stress As a natural xanthine derivative, structurally similar to endogenous purine nitrogenous bases, caffeine is metabolized almost entirely and involves both microsomal (especially CYP1A2) and non-microsomal enzyme xanthine oxidase (XO)see Figure 2