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Secondary endpoints included AUEC for positive PE for 5240 min (AUEC PEpos 5240 ), maximum positive PE (E max PEpos ), AUEC for negative PE for 5240 min (AUEC PEneg 5240 ), maximum negative PE (E max PEneg ), minimum UTS (E min UTS ), AUEC for UTS for 015 min (AUEC UTS 015 ), AUEC for UTS for 0240 min (AUEC UTS 0240 ), and effect of OPL (E overall PL ) at 240 min