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As previously discussed, neurodegenerative and autoimmune disorders such as AD, MS, and PD are associated with reduced GSH concentrations in the brain making supplemental GSH an attractive therapy if the limitations in delivery can be overcome (Smeyne and Smeyne, 2013)

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More importantly, PEGylation has already been established in extending the circulation life of various therapeutics, including proteins and small molecules, which in turn drives substantial progress in biologics development and drug-loaded nanoparticles (120)

Further research is essential to discover new strains, optimize dosing regimens, confirm safety, and validate health claims through robust clinical trials