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78 These DAMPs play a major role in promoting neutrophil infiltration by activating antigen-presenting cells, including Kupffer cells and dendritic cells, which amplifies the immune response and the progression of liver injury

Optimal effects typically observed with regular treatment protocols

In the mechanism of DKD, in addition to Kelch-1ike ECH-associated protein l (Keap1)/Nrf2/antioxidant response element (ARE) signaling, Nrf2 can inhibit inflammation to relieve kidney damage by suppressing NF-B, Sirtuin1 (SIRT1) and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)[104, 126]