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The FDA noted that retailers receiving these warning letters are selling or distributing e-cigarettes that lack the agency's authorization

However, in more traditional families, Double Happiness cigarettes are still included for symbolic continuity

Finally, methylation levels are often correlated across multiple neighboring CpGs and this co-methylation is stronger for CpGs inside CGIs than outside CGIs ( ENZYMES OF DNA METHYLATION Methylation of DNA is catalyzed by three families of DNA methyltransferases: DNMT1, DNMT2, and DNMT3 ( DNMT1 is responsible for life-long maintenance of DNA methylation during cell division it copies DNA methylation marks from the original to the nascent strand during DNA replication (Tang et al., 2009)