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Moreover, a recent study demonstrated that Boswellia carterii n-hexane extract (BCHE) significantly inhibited the viability of human breast cancer cells and displayed potent in vivo anti-breast cancer activity without notable toxicity, inducing ferroptosis by upregulating transferrin expression and intracellular Fe 2+ levels, downregulating glutathione peroxidase 4 (GPX4), and promoting ROS mediated lipid peroxidation in both breast cancer cells and tumor-bearing mice, suggesting BCHE as a potential therapeutic candidate for ferroptosis-targeted breast cancer treatment (Xie et al., 2024)

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