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In particular, cigarette smoke acts as a double-edged sword that either exacerbates pathological immune responses or attenuates the normal defensive function of the immune system, possibly owing to the complexities and functional diversities of cigarette smoke components and individuals' medical condition

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9 Similarly, a 2024 study of legal cannabis in California found that most flower and flower products sold by legal California retailers test at 20 percent THC or greater and is now five to 10 times the level found nationally in cannabis studied in the 1970s and 1980s