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Adverse Effects of Smoking on the Body Smokers are at greater risk for cardiovascular diseases (ischaemic heart disease, hypertension), respiratory disorders bronchitis, emphysema, chronic obstructive lung disease, asthma), cancer (lung, pancreas, breast, liver, bladder, oral, larynx, esophagus, stomach and kidney), peptic ulcers and gastroesophageal reflux disease (GERD), male impotence and infertility, lindness, hearing loss, bone matrix loss, and hepatotoxicity