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Statistical analysis of patient base characteristics and clinical history was conducted with the MannWhitney U Test

Global sales of the genuine products were valued at $7 billion at the end of 2014 (compared with $800 billion for the regular tobacco market) and are forecast to reach $51 billion by 2030, according to Euromonitor International

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A 2017 meta-review of studies about tobacco control policies produced the following scorecard. Each intervention was graded on its impact on relative smoking rates on a short-term (5 year) and long-term (40 year) basis, with both a best estimate and a range reflecting the scope of study results