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RO4929097 (an inhibitor of Notch signaling pathway, -secretase inhibitor) combined with erlotinib could improve the efficiency of erlotinib in advanced NSCLC with chemoresistance and the PFS was up to 5 years ( NCT01193881 (first posted: 2 September 2010), NCT01193868 (first posted: 2 September 2010) )

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