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The FDA requires e-liquid product labels to abide by the following rules: Nicotine Disclaimer : Labeling must include the statement, WARNING: This product contains nicotine

A study in rats also investigated the influence of gestational nicotine on the offsprings sensitivity to natural and drug rewards [ Another study showed that sustained exposure to low doses of nicotine (3 mg/kg/day) during fetal development produced substantial changes in the developing corticostriatal dopamine system including both sex-dependent and sex-independent effects on the prefrontal dopamine systems [165]

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Together, these effects reduce oxygen supply more than either one alone