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Of these subjects, 1208 (62.9%) underwent the 20th examination and had at least 1 year of follow-up data

found that the dysregulation of zinc homeostasis in esophageal tumorigenesis is mainly reflected in the upregulation of ZIP5 and the downregulation of the zinc metabolism protein MT1G using cDNA microarray

This pathophysiological triad is further compounded by oxidative stress [reactive oxygen species (ROS)-mediated endothelial and mitochondrial dysfunction], establishing a self-reinforcing cycle (89)

The short duration of the intervention (eight weeks) may not capture the long-term effects or sustainability of the intermittent fasting regimen