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This approach allows me to change and adjust the fertilization regimen, the way I grow my tobacco, and I can also adapt the curing process according to my customers requests. Full control all the way Having taken over the family business in 1997, Mantovanelli closely directs and controls every single step in the production process and makes all decisions: seed choice, transplanting, fertilization, the right harvesting time, as well as the curing, grading, and storage of each batch at the perfect temperature and humidity

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Methylation involves the enzymatic addition of a methyl group to the 5 positions of cytosine, using S-adenosyl-methionine as the methyl donor, a process catalyzed by DNA methyltransferases DNMT1, DNMT3a, and DNMT3b (Kulis and Esteller, 2010