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Via the catalytic activity of a broad superfamily of phase II detoxification enzymes, the Glutathione STransferases (GSTs), glutathione is covalently conjugated to electrophilic xenobiotics and endogenous reactive intermediates

Simultaneously, the activation of plaque macrophages by CD4 + T lymphocytes through CD40LCD40 signaling amplifies pro-inflammatory cytokine secretion, promotes macrophage polarization towards the M1 phenotype, and recruits immune cells, collectively perpetuating plaque instability

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Make sure to have medical records with an ADHD and/or autism spectrum disorder diagnosis with you when you speak to an attorney