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Oxidative stress arises from an imbalance between reactive oxygen species (ROS) and cellular antioxidant defenses, contributing to DNA damage, protein misfolding, and cellular aging

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It plays a role in critical cellular processes, such as neural cell differentiation, 2 myelination by oligodendrocytes, 3 neurotransmitter synthesis and breakdown, 2 and programmed nerve cell death through ferroptosis

The injury is most often associated with anatomical abnormalities of the pelvis, which leads to knee valgus