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Although protein aggregation is a common feature, neurodegenerative diseases exhibit different patterns of neurons loss and affect distinct regions of the CNS (Dugger and Dickson, 2017)

How to tell if peptides have degraded Visual inspection (reconstituted) Fresh peptide solution should be : Clear (transparent) Colorless (or very slight tint) No particles or cloudiness No discoloration Signs of degradation : Cloudiness or haziness Yellow or brown tint Visible particles floating Crystallization Oily film on surface If any of these present : Don't use, peptide has degraded

BMC Cancer 21 , 28 (2021)

However, the predicted amino acid sequence (denoted eCATH-4 in this review) is included in Figure 3 and the corresponding gene information in Table 2