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4 Bidirectional crosstalk between neuroinflammation and ferroptosis in depression Although the individual roles of neuroinflammation and ferroptosis in the development of depression have received considerable attention, the bidirectional crosstalk between these processes and their specific molecular pathways remains relatively unexplored

In line with the above argument it has been shown that the mechanism of restoration of endothelial function is related to favorably increased the [NO]/[ (ONOO-)] balance, enhanced endothelial cytoprotective NO, decreased cytotoxic (ONOO-) (8)