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This is critical: Angle the needle so the stream of water runs down the inside wall of the glass vial

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In addition there is concern about increasing antibiotic resistance and NICE has identified UTI infections as a key area, in terms of how infections can be managed, with the purpose of tackling antibiotic resistance

109(10): 1866-1872 (2013) Fusco, V., Fanelli, F., & Chieffi, D