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Previous literature has demonstrated that GSH levels are elevated in various tumors, including breast, colon, laryngeal, gastric, and lung cancers [16]

4.2 Targeting Gln metabolism to inhibit tumor proliferation 4.2.1 Inhibition of Gln uptake Tumor survival and proliferation are heavily dependent on Gln, a hydrophilic amino acid that must be transported into tumor cells by transmembrane proteins, such as SLC1A5, SLC6A14, and SLC38A1/2

In contrast, cell lines expressing GSTP1 exhibited an unmethylated and transcriptionally active promoter thus confirming a relationship between hypermethylation and repression of GSTP1 expression (Karius et al., 2011)