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IGF-1 LR3 is not a licensed medicine or drug and has not been approved by the MHRA, FDA, or any regulatory authority for use in humans or animals

Introduction Platinum (Pt) drugs, such as cisplatin (CP), oxaliplatin (OXA), and carboplatin, are commonly used in the treatment of colorectal cancer (von Minckwitz et al., 2014), and lung cancer ( 2 ), singlet oxygen ( 1 O 2 ), hydrogen peroxide (H 2 O 2 ), hydroxyl radical (OH), and so on, would induce oxidative damage to biomolecules (e.g., proteins, lipids, and DNA) and, thus, lead to severe cellular damage ( 2 ( 2 ( To solve the challenge, numerous researchers devote to exploring the mechanism of PIPN, which are principally implicated in transporter overexpression (Sprowl et al., 2013), ROS upregulation (Stanford et al., 2019)