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Moreover, the number of senescent cells also increase with culture time, resulting in a loss of division capabilities, resistance to apoptosis, and the acquisition of a robust proinammatory secretome known as the senescence-associated secretory phenotype (SASP) (Jeon et al., 2018)

Malenka, R

This is especially important for patients who have any GI-related problems: reflux/heartburn, SIBO/SIFO, chronic constipation, leaky gut, patients who are on acid blockers, etc