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These obstructions made of keratin, cellular debris, granulation tissue, and/or fibrosis can increase stress, contribute to progression of disease, result in lid tenderness, inflammation, recurrent eyelid infections (styes, hordeola, chalazia, cellulitis), and other symptoms of ocular irritation, and can exist simultaneously with traditional MGD

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Enhanced blood flow via VEGF and nitric oxide pathways may benefit uterine and ovarian function